In the first week
(21-27 April) I started with my internship at the department of bioinformatics at
Maastricht University. The project is from Egon Willighagen and it is about searching
a new solution to cure Malaria by using systems biology. I will try to use a systems
biology approach to analyse and to find a target which plays a role in the
development of Malaria.
In ArrayExpress I search for dataset in which malaria was compared between healthy persons. From all the founded dataset I made a table. Finally I chose for a known dataset which I will further use in which they tested the changes in gene expression in people
and with and without Malaria. In the subjects with Malaria they also tested the
differences between pre-symptomatic and symptomatic changes in the disease. And thereafter I will read some articles of
people which did some research in the field of the effects of Malaria and a
cure for Malaria and try to find some inks between them. And if possible even
find a new cure to fight Malaria.
In this
first week I have read some articles which I could use for my project.
In one article the author compared four different
groups (a baseline, a group which they gave malaria, a group which has acute
malaria, and a last group which is treated from malaria). Because I though this
article might be useful for my project I run the dataset in arrayanalysis.org at
the end of this week and planned to take a look at the results next week.
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